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SOPHiA for Radiomics is a groundbreaking application that analyzes medical images and combines them with biological and clinical data to predict tumor evolution. This powerful radiomic solution supports clinicians in choosing the right therapeutic strategy for a given patient. The aim of the pilot was to show that Radiomics for glioblastomas (GB) and Non-Small Cell Lung Cancer (NSCLC) , have the ability to enhance diagnosis, prognosis along with following the progression of the disease and assessing the therapeutic response. These applications have shown to be relevant for clinicians and radiologists at DASA.